Tacrolimus ointment is the first in the new class of steroid free topical immunomodulators tims and as such represents the first true breakthrough since the introduction of topical steroids more than 50 years ago for the treatment of t cell mediated inflammatory skin diseases such as atopic dermatitis. Request pdf tacrolimus ointment a topical immunomodulator for atopic dermatitis therapeutic break throughs in medicine are usually accompanied by a wealth of data often they result in a . Tacrolimus ointment is the first in the new class of steroid free topical immunomodulators tims and as such represents the first true breakthrough since the introduction of topical steroids more than 50 years ago for the treatment of t cell mediated inflammatory skin diseases such as atopic dermatitis. Tacrolimus ointment is the first in the new class of steroid free topical immunomodulators tims and as such represents the first true breakthrough since the introduction of topical steroids more than 50 years ago for the treatment of t cell mediated inflammatory skin diseases such as atopic dermatitis