Regulatory t cells can be best thought of today as teenagers ready to take on all the challenges of complex immune responses in ten years the field will certainly be more mature and manipulation of regulatory t cell function by cellular biotherapy antibodies and small molecules will be routine function of the clinical immunologist. Regulatory t cells can be best thought of today as teenagers ready to take on all the challenges of complex immune responses in ten years the field will certainly be more mature and manipulation of regulatory t cell function by cellular biotherapy antibodies and small molecules will be routine function of the clinical immunologist. Increasingly transplantation research focusses on regulatory t cell treg therapy to achieve this aim in which treg are used as a strategy to allow reduction of immunosuppression currently the first clinical trials are underway investigating the safety and feasibility of treg therapy in renal transplantation. Other cell types that will be investigated in the one study are t regulatory type 1 cells tolerogenic dendritic cells and regulatory macrophages the main aim of this study will be to investigate the feasibility of gmp manufacture of regulatory immune cells for clinical use and the safety of cell infusion